Kethoxal bis(thiosemicarbazone). II. Toxic and pathologic effects.
نویسندگان
چکیده
carcinosarcoma 256 (7, 10) was markedly inhibited by kethoxal bis(thiosemicarbazone). After discontinuation of treatment the inhibition was persistent and was followed by complete tumor regression in a substantial percentage of cases (7). Moreover, KTS2 inhibited the growth of 5 other transplantable rodent tumors (7, 10). Impairment of spontaneous mammary tumors was caused by KTS in DBA/2 (7), C3H (10), and BALB/c X DBA/8 F1 (CD8F1) (4) mice.
منابع مشابه
Inhibition of the Growth of Sarcoma 180 Ascites Cells by Combinations of Inhibitors of Nucleic Acid Biosynthesis and the Cupric Chelate of Kethoxal Bis- (thiosemicarbazone)l
The tumor-inhibitory jxitency of combinations of the cupric chelate of kethoxal bis(thiosemicarbazone) [Cu(II)KTS] with several compounds that cause inhibition of the synthesis of DNA by different biochemical mechanisms was assessed in Sarcoma 180 ascites cells. Cu(II)KTS prolonged the survival time of tumor-bearing mice, whereas neither cupric chloride, copper stéarate,nor kethoxal bis(thiose...
متن کاملInhibition of the growth of sarcoma 180 ascites cells by combinations of inhibitors of nucleic acid biosynthesis and the cupric chelate of kethoxal bis-(thiosemicarbazone).
The tumor-inhibitory jxitency of combinations of the cupric chelate of kethoxal bis(thiosemicarbazone) [Cu(II)KTS] with several compounds that cause inhibition of the synthesis of DNA by different biochemical mechanisms was assessed in Sarcoma 180 ascites cells. Cu(II)KTS prolonged the survival time of tumor-bearing mice, whereas neither cupric chloride, copper stéarate,nor kethoxal bis(thiose...
متن کاملThe antitumor activity of Cu(II)KTS, the copper (II) chelate of 3-ethoxy-2-oxobutyraldehyde bis(thiosemicarbazone).
The antitumor activity of the copper(H) chelate of 3-ethoxy-2oxobutyraldehyde bis(thiosemicarbazone), Cu(II)KTS, against the Walker 256 carcinosarcoma in rats is shown, and the im portance of considering this chelate as the active intermediate in the mechanism of action of the free ligand, KTS, is indicated. The potentiation of the antitumor activity and toxicity of Cu(II)KTS by KTS and Vu(II) ...
متن کاملA model system for detecting drug impairment of antitumor host defenses.
A model system was developed taking advantage of the fact that the complete regression of Sarcoma 180 in vitamin Be-deficient Swiss mice is due to the immunological response of the host directed against the tumor. By comparing the effects of drug treatments given before or after tumor implantation, it was possible to dissociate the antitumor from the antihost effects of the drugs tested. The mo...
متن کاملPrevention of therapeutically induced regression of sarcoma 180 by immunologic enhancement.
The increased incidence of regression of Sarcoma 180 observed in Swiss tlaICt~ mice fed vitamin B(vdeficient diet or treated with 6-mercaplopurine or kethoxal-bis (thiosemicarbazone) was greatly reduced by active imnmnization of the host with frozen-thawed Sarcoma 180 homogenate or by passive transfer of specific hyperimmune serum. Similar results were obtained in C57BL/6 mice implanted with a ...
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عنوان ژورنال:
- Cancer research
دوره 25 9 شماره
صفحات -
تاریخ انتشار 1965